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People who may need to avoid taking Lexapro include: 1 Kidney problems Liver problems Heart problems Bipolar disorder or mania Prior allergic reactions to escitalopram Prior vision issues such as glaucoma A history of seizures Low sodium levels in the blood Bleeding problems Drug Interactions With Lexapro Taking certain medications, herbs, or supplements alongside Lexapro can change how Lexapro works in your body or increase the risk for serious side effects